Effects of escitalopram on menopause-specific quality of life and pain in healthy menopausal women with hot flashes: a randomized controlled trial.

نویسندگان

  • Andrea Z LaCroix
  • Ellen W Freeman
  • Joseph Larson
  • Janet S Carpenter
  • Hadine Joffe
  • Susan D Reed
  • Katherine M Newton
  • Rebecca A Seguin
  • Barbara Sternfeld
  • Lee Cohen
  • Kristine E Ensrud
چکیده

OBJECTIVE To evaluate the effects of escitalopram 10-20 mg/day on menopause-related quality of life and pain in healthy menopausal women with hot flashes. STUDY DESIGN A double-blind, placebo-controlled randomized trial of escitalopram 10-20mg/day vs. identical placebo was conducted among 205 women ages 40-62 years with an average of ≥4 daily hot flashes recruited at 4 clinical sites from July 2009 to June 2010. MAIN OUTCOME MEASURES The primary trial outcomes, reported previously, were the frequency and severity of vasomotor symptoms at 8 weeks. Here, we report on the pre-specified secondary endpoints of total and domain scores from the Menopause-Specific Quality of Life Questionnaire (MENQOL) and the pain intensity and interference scale (PEG). RESULTS Outcome data were collected on 97% of randomized women and 87% of women took at least 70% of their study medication. Treatment with escitalopram resulted in significantly greater improvement in total MENQOL scores (mean difference at 8 weeks of -0.41; 95% confidence interval (CI) -0.71 to -0.11; p<0.001), as well as Vasomotor, Psychosocial, and Physical domain scores with the largest difference seen in the Vasomotor domain (mean difference -0.75; 95% CI -1.28 to -0.22; p=0.02). There was no significant treatment group difference for the Sexual Function domain. Escitalopram treatment resulted in statistically significant improvements in PEG scores compared to placebo (mean treatment group difference at 8 weeks of -0.33; 95% CI -0.81 to 0.15; p=0.045). CONCLUSIONS Treatment with escitalopram 10-20mg/day in healthy women with vasomotor symptoms significantly improved menopause-related quality of life and pain.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

The Effects of Valerian Root on Hot Flashes in Menopausal Women

Hot flash is among the most common complaints of menopausal women, affecting their career, social activities and quality of life. This study aimed to investigate the effects of Valerian on hot flashes in menopausal women. In this double blind clinical trial, 68 menopausal women with the chief complaint of hot flash were enrolled using sampling at hand and were randomly divided into drug and pla...

متن کامل

The Effects of Valerian Root on Hot Flashes in Menopausal Women

Hot flash is among the most common complaints of menopausal women, affecting their career, social activities and quality of life. This study aimed to investigate the effects of Valerian on hot flashes in menopausal women. In this double blind clinical trial, 68 menopausal women with the chief complaint of hot flash were enrolled using sampling at hand and were randomly divided into drug and pla...

متن کامل

Pnm-19: The Effect of Black Cohosh (CimicifugaRacemosa) on Vasomotor Symptoms in Postmenopausal Women: A Randomized Clinical Trial

Background: Hot flash is considered to be an early and common symptom of menopause. This symptom can interfere with the social and personal life of women; therefore, it demands a secure and effective intervention. Therefore, the present study aimed to determine the impact of black cohosh (Cimicifugaracemosa or actaearacemosa) on vasomotor symptoms in postmenopausal women. Materials and Methods:...

متن کامل

Efficacy of escitalopram for hot flashes in healthy menopausal women: a randomized controlled trial.

CONTEXT Concerns regarding the risks associated with estrogen and progesterone to manage menopausal symptoms have resulted in its declining use and increased interest in nonhormonal treatments with demonstrated efficacy for hot flashes. OBJECTIVE To determine the efficacy and tolerability of 10 to 20 mg/d escitalopram, a selective serotonin reuptake inhibitor, in alleviating the frequency, se...

متن کامل

The effects of red clover on hot flushes in post-menopausal women

Introduction: Hot flushing is one of the most common symptoms related to menopause which can lead to sleep deprivation, physical and psychological tiredness and disturbances in interpersonal relationships. In the recent years, tendency and desire toward alternative treatments, especially phytoestrogens, in relieving this symptom have been increased. Considering that red clover is the rich sourc...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Maturitas

دوره 73 4  شماره 

صفحات  -

تاریخ انتشار 2012